大鼠.小鼠无创血压仪mrbp -金沙1005

大小鼠无创血压测量系统（适合对大鼠小鼠进行无创式的血压测量，通过对鼠尾根部的实时检测，精确测量出大鼠、小鼠的收缩压、舒张压、平均压、心率，敬请来电咨询）

美国iitc生命科学仪器公司成立于1973年，其血压测量系统应用于全球的生命科学研究领域，经过不断的改进和拓展无创血压测量系统和测痛产品系列，其产品已用于全球实验室，也被数千篇国际论文所引用。

 

mrbp血压测量系统能够测量最少一只，最多同时200只动物，是经过验证的非常有效的手段和数据采集法，可以切实协助研究人员快速准确的在最低的推荐温度下对动物进行血压测量。

大小鼠无创血压测量系统的主要优势及特点：

ø 仅有的可测量从小鼠、大鼠、豚鼠到猴的血压设备

ø 采用光电传感技术测量原理，适用于麻醉、清醒状态下的动物血压测量

ø 内置软件，通过触摸操作屏控制，操作方便。也可通过电脑控制。

ø 测量参数：收缩压、舒张压、平均压、心率等

ø 充放气速率1-10 mmhg/秒可调

ø 自动充放气，尾套气压限值和测试截止压力值均可调，提高测试效率

ø 血压测量范围：0-300mmhg，精确度±5mmhg

ø 心率测量范围：0-1000 bpm

ø 液晶屏实时显示参数测量值和脉搏波形,并能存储、编辑、打印数据

ø usb直接储存数据功能

ø 可一次性独立或同时测试多至200只动物

ø 适用于核磁共振条件（mri）

mrbp大小鼠血压计的主要特色：

 

无创血压实验需要提高受测体周围环境的温度。理论上，较高温度时，测量血压的效果很好。我们可以通过控制鼠尾的血量来控制大小鼠的体温。当体温高于正常值时，流经鼠尾的血液就会散掉多余的热量。体温越高流经鼠尾的血液就越多。研究发现，加热大鼠的温度高于32摄氏度、小鼠温度高于34摄氏度时，会产生热应力，动物的热量就会损失一部分。这就影响了真正的血压值（改变了差不多+/-12-28 mmhg）

检测脉冲的形式非常重要，而传感器的选择决定了制作工艺。压电传感器多年来被广泛应用于麦克风和触碰开关。其原理是：对传感器施加外力后，产生电信号。但用这种传感器作为检测脉冲会有一系列的问题和缺陷：进行血压测量时有较高的温度需求（36-40℃）。

用晶体做的脉冲探测器也会出现一些问题和缺陷：进行鼠类的血压测量时所需要的温度高于热力学水平温度（36-40℃），而且加热尾部是基于“尾部脉搏是局部加热的结果”这一错误的假设。

1978年iitc发明了光电传感器，它将光和图片传感器用于脉搏的测量。当血流通过尾部，尾部血管直径的改变导致了光量得改变，直接导致光电量的变化。iitc原件的设计（感应电子设备和咬合袖带）不会像其他仪器一样，会对鼠尾产生机械性的作用力，同时如果需要可以精确地切断传感器。光电传感器可以在封闭的室温下进行检测，事实上许多使用本产品发表过的论文中，小鼠的起测温度要低于28℃，大鼠甚至更低。

与其他的高温法相比：

鼠类和其他动物一样有一个内在的调节机制，我们称为“温度调节”。正常的环境温度大概在26-27℃，如果环境温度高于正常温度（28-30℃），“温度调节”开始增加血液流量。这样会导致尾部会有更多的血液流量，由于尾部是身体的一部分而并不是简单的皮革的覆盖，所以会自行降温以求尽快散热。这就是间接测量血压的原理。

mrbp大小鼠血压计最大的不同在于脉搏探测器上。它能在26℃或者更低的温度下进行测量。而其他脉搏探测器由于不够敏感就会要求更高的温度。温度过高会使动物死亡的风险大大增加。

大小鼠无创血压仪的部分参考文献：

geraniol improves endothelial function by inhibiting nox-2 derived oxidative stress in high fat diet fed mice

x wang, s zhao, m su, l sun, s zhang, d wang… - biochemical and …, 2016 - elsevier

... hfd controls; n = 20) for 6 weeks. after 6 weeks, systolic blood pressure was measured
using tail cuff plethysmography (iitc life science mrbp blood pressure system). the
mice were deeply anaesthetized with sodium pentobarbital ...

disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress

s li, l zhang, r ni, t cao, d zheng, s xiong… - … et biophysica acta (bba …, 2016 - elsevier

... animals were acclimated in the environment for 5–10 min after occlusion cuffs and pulse
transducers (mrbp system, iitc life science, usa) were placed on the tail. the values of
at least 10 readings for each mouse were used for blood pressure. 2.4. ...

influence of p2x receptors on renal medullary circulation is not altered by angiotensin ii pretreatment

m kuczeriszka, l dobrowolski, a walkowska… - pharmacological …, 2016 - elsevier

... we confirmed that with this procedure systolic blood pressure (tail-cuff method,
mrbp-3r, iitc inc., woodland hills, ca, usa) increased gradually to about 190 mmhg,
compared to about 130 mmhg measured in untreated sd rats. ...

protective effects of at1-receptor blocker and ca antagonist combination on renal function in salt loaded spontaneously hypertensive rats/протективни ефекти …

k gjorgjievska, d zafirov, m jurhar-pavlova… - prilozi, 2015 - degruyter.com

... function tests. sbp was measured by a pletismografic method (iitc life science
mrbp blood pressure system, california, usa) on the rats tail. body weight was
measured every second week of treatment. renal functional ...

the synthetic tie2 agonist peptide vasculotide protects renal vascular barrier function in experimental acute kidney injury

e rübig, j stypmann, p van slyke, dj dumont… - scientific …, 2016 - ncbi.nlm.nih.gov

... immediately before the first ultrasound examination, average blood pressure and heart rate
were measured via tail cuff in each animal (5 measurements) using the mouse blood pressure
system mrbp-m01 (iitc life science, woodland hills, ca, usa). ...

changes in protein and gene expression of angiotensin ii receptors (at1 and at2) in aorta of diabetic and hypertensive rats

r romero-nava, je rodriguez… - clinical and …, 2016 - taylor & francis

... systolic blood pressure (sbp) and heart rate were measured by a non-invasive blood pressure
tail-cuff method (mrbp blood pressure system, iitc, life science, woodland hills, ca) by
photoelectric detection in the rat tail and blood glucose levels were measured with a ...

low-dose insulin treatment ameliorate glucose metabolism in type 1 diabetic rats. j diabetes metab 7: 635. doi: 10.4172/2155-6156.1000 635 page 2 of 8 …

axh ng, sh ton, ka kadir - 2016 - researchgate.net

... the blood pressure of rats were measured once every week using the mrbp mouse and rat
tail cuff method blood pressure system (iitc life sciences, usa). the tail cuff with pulse
transducer was applied onto the tail of the rat placed in a plastic restrainer. ...

benefício da utilização do novo alimento funcional salgante sem sódio sobre os níveis de pressão arterial em animais hipertensos

fsm rodrigues, ma yasuda, l de paula… - revista de pesquisa …, 2015 - pgsskroton.com.br

... os parâmetros foram aferidos através de método não invasivo (indireto) utilizando equipamento
mrbp (mouse rat blood pressure- iitc life science) nos dias zero (sem tratamento com nacl
ou salgante - pó de aspecto cristalino, branco e fino, solúvel em água, com odor ...

 

 

asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressureulcers

b fromy, e lingueglia, d sigaudo-roussel… - nature medicine, 2012 - nature.com

... the experimental protocol was approved by the scientific and ethics committees of the university
claude bernard lyon 1, france (no. ... blood pressure was monitored noninvasively throughout
the experiment using a tail cuff system (iitc inc/life science instruments). ..

《nature medicine》,五年影响因子高达27.887）

salt–sensitive hypertension and reduced fertility in mice lacking the prostaglandin ep2 receptor

crj kennedy, y zhang, s brandon, y guan… - nature medicine, 1999 - nature.com

... mouse blood pressure was measured using an iitc life science model 27 cuff pump with a
model 179 blood pressure analyzer. pressure was measured at 30 °c and was initiated as
cuffs were inflated to 200 mm hg and deflated at a rate of 3 mm hg/sec. ...

chronic β-adrenergic stimulation induces myocardial proinflammatory cytokine expression

dr murray, sd prabhu, b chandrasekar - circulation, 2000 - am heart assoc

... system–audie murphy division, san antonio, tex (drm, bc), and the university of louisville
health sciences center, louisville ... 1 · d −1 , n=8) or saline (n=7). after anesthesia, measures
of body weight, blood pressure, and heart rate (tail cuff, iitc life science model 29 ...

 

circulation 最新的影响因子为15.202 (2013) ,该杂志 2011年在 cardiac & cardiovascular systems （心血管） 同类期刊中的影响因子排名第 1位。

endogenous ligand of α1 sodium pump, marinobufagenin, is a novel mediator of sodium chloride–dependent hypertension

ov fedorova, mi talan, ni agalakova, eg lakatta… - circulation, 2002 - am heart assoc

... systolic bp (sbp) was measured weekly by tail-cuff plethysmography (iitc model 31, iitc life
science). ... 1969; 1 (suppl 24, 25): 21–33. ↵ blaustein mp. sodium ions, calcium ions, blood
pressure regulation and hypertension: a reassessment and a hypothesis. am j physiol. ...

 

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